Witchblade is one of those series that probably could (should) have been quite a few episodes shorter. That being said, there are some really cool action scenes, the animation is good, and the plot is enough to keep you interested throughout. Witchblade doesn't introduce any new concepts to anime - people turning into powerful weapons capable of destroying entire cities is the key here. It's kind of like mech anime but with busty, nearly-naked chicks wearing a small amount of armor.
Masane Amaha lost her memory after an event called "The Great Quake" and awoke with a baby in her arms. She raises the child, Riko, although she faces the challenges of motherhood alone. The government's Child Welfare Division seems to have an interest in taking Riko away from Masane and the two are always on the run from them. Eventually, Masane unwittingly becomes the bearer of the Witchblade (a device attaches to her wrist and she can transform into the "weapon") and is forced to work for a corporation that creates living weapons using reanimated corpses and science. What Masane doesn't know is that having the Witchblade is irreversible and carries significant consequences.
Most of the episodes either focus on Masane and her daughter and their new friends in the apartment they rent, or Masane transforming and fighting against other human weapons who want her power for themselves. About 10 episodes back from the end of the series, most people can probably figure out what will happen at the end. Still, the last several episodes are spent basically dragging out the inevitable with plenty of filler material. That being said, when the fight scenes are on they are really, really cool. The plot involving Masane's daughter is also somewhat heartwarming, although that is mostly because she is super cute. The ending is pretty decent, although since it has been beaten to death by the time you get to the final episode, you already know what is going to happen. This series is a fun and entertaining watch, just don't expect it to break any new ground.