Cadis Etrama Di Raizel, the Noblesse, wakes up from his 820 year old, mysterious, slumber. The Noblesse meets his follower / servant Frankenstein who is a school dean. Frankenstein explains to his "master" that the world has changed during his slumber, and he then invites his master to his school. Cadis Etrama Di Raize meets Han Shinwoo and his friend who gave him the nickname Rai. They all become good friends, but when two people M-21 and M-24 abduct the children, Rai and Frankenstein have to save them. Rai and Frankenstein learn that these two work for a company called "The Union," a place where the government does experiments to enhance human capabilities. While Rai and Frankenstein try to solve the mystery as to why Rai was sleeping for so long, they also have to figure out the purpose behind The Union's experiments.