The content below is entirely editable.
The Vatican, the home of Catholicism and the Pope, occasionally plays a part in some anime with a religious or spiritual theme behind it.
In real life, Vatican City is a landlocked sovereign nation within the city of Rome, overseen by the Pope of the Catholic Church (also known as Sovereign of the State of the Vatican City).
In some anime, such as Chrono Crusade or Trinity Blood, The Vatican is seen as the be-all end-all of Christianity, home to everything from the Inquisition to various warrior nuns. Even in hellsing has a vampire hunting organization about 13 sections and they are all named after Jesus and the rivals of the hellsing organization.