Tsunade Enemies

Hanzo was the leader of the Rain village whom fought Jiraiya, Orochimaru, and Tsunade in their youth and is the one that dubbed them the "Sannin." He was infamous and revered in all ninja villages.

Madara is one of the founders of Konoha ,The Akatsuki ,and leader of the Uchiha Clan of but was betrayed and lost to Hashirm Senju. His successor is Obito Uchiha aka Tobi and is working for him.He was revived by Kabuto and the creator of the Moon Eye's Plan.

Manda is the giant summoned Snake of Orochimaru and later Sasuke Uchiha. He is classed in with the other Sannin Summons, Katsuyu and Gamabunta.

Menma is the son of Kushina Uzumaki and Minato Namikaze from an alternate dimension. He is an evil version of Naruto and possibly secondary antagonist in Naruto Road to Ninja.

"Tobi" is Obito Uchiha ,Kakashi's teammate and the one who gave him his Sharingan eye. He is working for Madara Uchiha and is leader of Akatsuki, he is the one who unleashed the nine tails on Konoha and cause of many other horrible deeds in the series.

Orochimaru, one of the Legendary Sannin, yet a vile monster , mostly a snake like person, twisted and mindless, he is the definition of pure evil and the ones who follow.He was one of the main villains of Naruto Until he meets his end by Sasuke Uchiha.