Tsunade Enemies

Hanzo was the leader of the Rain village whom fought Jiraiya, Orochimaru, and Tsunade in their youth and is the one that dubbed them the "Sannin." He was infamous and revered in all ninja villages.

Manda is the giant summoned Snake of Orochimaru and later Sasuke Uchiha. He is classed in with the other Sannin Summons, Katsuyu and Gamabunta.

Orochimaru, one of the Legendary Sannin, yet a vile monster , mostly a snake like person, twisted and mindless, he is the definition of pure evil and the ones who follow.