Tsume is one of four main protagonists in the anime, OVA and manga series, Wolf's Rain, by writer and story editor Keiko Nobumoto and BONES, and directed by Tensai Okamura.
Tsume is a grey wolf with a white scar on his chest and is the second wolf introduced in the series, Wolf's Rain. At first he was living in Freeze City where he led a "pack" of human thieves. He clashed with Kiba over the latter's claims that Tsume had lost his pride as a wolf for living with humans as he did. Later, he connected with Toboe, a young wolf who also lived in the city. Though Tsume claims he has no need for friends and that he wants nothing to do with other wolves, he comes to Toboe's aid twice and shares a meal with him. Though he doesn't believe Kiba's stories about Paradise, he decided to leave the city with him to search for the place under the excuse that he was tired of the city.
Tsume is depicted as a "a stereotypical angry anime loner" and an "emotionally distant hottie" who is confident, and at times arrogant, but keeps himself distant from his allies. Though he and Kiba continue to come into regular conflict, Tsume eventually comes to believe in their goal and becomes a loyal pack member. It is eventually revealed before moving to Freeze City, he had lived in another location with a large pack of wolf's. Jaguara's wolf hunting troops attacked the pack, killing most of his family and friends. As Tsume attempted to flee from the battle, he was cast out by his pack and the alpha male attacked him, leaving Tsume with a large X-shaped scar across his chest. Tsume eventually traveled to Freeze City where his self-loathing over his actions caused him to refuse to befriend others.
Of all of the pack, he is closest to Toboe, whom he refers to as "runt." After the young wolf is killed by Darcia, Tsume cries over his body. Tsume is the last of the pack to remain standing with Kiba in the final battle with Darcia. He is killed after Darcia rips open his side and legs. Before dying, he whispers to Kiba that "we shall meet again.... in paradise." At the end of the series, Tsume is seen in his human form riding a motorcycle in a city