High school student Tohru Honda is living in a tent while her grandfather makes renovations to his home. As Tohru leaves the tent while on her way to school, she comes across a house with figurines of the 12 zodiac animals freshly painted being dried out. She talks to a man in robe regarding the lack of a cat present with the figurines as the cat wasn't a part of the zodiac which was Tohru's favorite zodiac animal. To her surprise, Tohru learns that this house is the home of class rep and 'prince' Yuki Sohma and his cousin, Shigure. With their meeting, Yuki and Tohru decide to walk together to school.
This gets the attention of the Yuki Fan Club members, a club of girls who are literally fans of Yuki. They try getting answers out of Tohru about walking with Yuki and intimidating her. But, they get scared off by the presence of Tohru's best friends, Saki Hanajima and Arisa Uotani. During their cooking class, Saki comments that she senses something strange coming from Yuki. Arisa agrees with this considering how mysterious Yuki acts and the rumor of how he actted towards a second-year female student who tried to hug him.
At the end of the day, Yuki and Tohru walk together from school. Yuki asks Tohru of her conversation regarding the cat of the zodiac. He remarks that he hates the cat and the connection that it has to the zodiac. He then comments on Tohru looking pale saying she should take better care of herself. Following their conversation, Tohru goes to her part-time job as a janitor in a office building remarking that she must give her all to achieve her dream of graduating high school as her mother wished.
Later on, Yuki and Shigure are walking home from eating out when they notice Tohru arriving back at her tent looking sick. After Shigure chuckles from what he is seeing, both he and Yuki have Tohru explain her situation back at their house. Shigure warns Tohru that the cliffside she is near is prone to landslides. He hears a wolf howling and comments that a landslide was just triggered. Arriving back at the tent site, Tohru is shocked to see her tent buried in the landslide. Franctic, she tries digging up the rubble to get her mother's photo. But, she is too exhausted from her fever to do too much. Shigure tells her not to push herself too much and the three go back to the house.
Tohru is resting in a bedroom as she tells Shigure of her struggle to make her mother's wish a reality of graduating high school when she could not. As Tohru drifts off to sleep, Yuki says that he is amazed of Tohru's independence despite her hardships commenting how he lacked the resolve to be that carefree. He then leaves Shigure to care for Tohru as he gets 'help' to dig up Tohru's personal possessions.
The next morning, Tohru wakes up to find a photo of her mother alongside the futon she is sleeping in. Yuki arrives in her bedroom telling her that he dug up her possessions. Shigure arrives afterward telling her that she is free to stay with them until her grandfather's renovations were completed under the condition that she did the housework to repay them.
Yuki lends Tohru some clean clothes and takes her up to an empty bedroom that she can use for herself during their stay. As Yuki opens up a window to air out the house, an orange-haired boy comes crashing through the roof of the house trying to instigate Yuki into a fight. As Tohru grabs onto the boy to keep him from fighting, a poof of smoke appears and to Tohru's surprise, the boy transformed into a cat. Shigure arrives upstairs curious if their cousin, Kyo, had arrived. A bewildered Tohru thinks that the transformation was an accident as she franctically tries to call a doctor. However, a piece of wood from the roof of the house falls down and clonks Tohru on the head. Dazed, Tohru falls into Yuki and Shigure. Two more poofs appear and a rat and dog appear in their place leaving Tohru even more bewildered.