Well, in a year full of Twilight and Vampire Diaries hypes and other crappy vampire stories, Shiki comes as a refreshing drink. That's how a vampire story has to be. The feeling of suspense and horror, deaths and plot twists. If you can't have this in a vampire story than it's not vampires you're dealing with. It's just some shiny metrosexual guy with fangs.
The story of Shiki is absolutely outstanding. Full of plot twists, heart racing revelations and it gets to a point where you're not absolutely sure which side to support, vampires or humans. While the first half of the anime is for story and suspense development, the second half focuses on the war between the two species.
The art is amazing as well. The sceneries are well detailed, the characters are really well drawn and it always enhances the feelings that are supposed to be conveyed.
The soundtrack, as the art, never fails to help enhancing the atmosphere. Takanashi Yasuharu had already done a great job in Ayakashi: Japanese Classic Horror and in Jigoku Shoujo, among others, and showed his skills once again in this amazing anime.
Possibly the strongest point in this series, the character development is unique. Vampires or humans, all of them are deep and act accordingly to what could be expected in the situation they are. Some will often make you have twisted feelings towards them.
With so many great aspects this is by far and large the best show in 2010. I enjoyed watching until the very last episode and hopefully there'll be a second season.
So, if you're looking for suspense and vampiries, look no more. Shiki is the one!;D