@phantomrant: TBB's take some time to charge up. I see Hashirama being more of a problem here given his big ass Buddha, with which he can spam thousands of punches simultaneously.
Naruto and Bee has been shown firing them off nigh-instantly some dozens of chapters/few years ago.
As for his Buddha. It's pretty hard for all of those punches to accurately hit three human-sized targets -.-
All 3 Bleach top tiers have enough speed and stamina to keep their distance from the Buddha. What they cannot avoid however are cutting air slashes and a TBB. Hashirama is more suited in fighting straight-up powerhouses who are not too hax, because it's just a simple matter of tagging them and murking them. With Yamamoto's inclusion in the team, it's unlikely that his wood constructs would hold up against a 15 million degree reiatsu aura.