@FalconC2: Prove that Luke is capable of lightspeed reactions. Honestly I wouldn't have expected this from you.
This thread is a mismatch and should have been locked ages ago.
And just to give you food for thought, remember when Piccolo blew up the moon? He fired an attack that reached it in a couple of seconds, and that was at the start of DBZ. Luke fights sith lords who can terrorize planets and dodges blaster bolts and laser blasts (not FTL at all), Goku and co take out planet-busters on a weekly basis.
True, how fast was that though? I mean, I know it would take light around 1.3 seconds to reach the moon from earth IIRC. In the manga, how long did Piccolo's beam take to reach the moon exactly? As far I know, it has no official time frame.
I'm just going by the feats provided by Supreme Marvel, if Luke can react to things moving at relativistic speed and stuff, that combined with his powerful telepathy would give him a good shot at KO-ing Goku. I don't think Goku's fast enough to stop him from doing that.