Dream (Level 20)

This implies with the two-part "Second Renaissance" short that explores the events that led up to the robotic takeover from humanity. And of course, it sucks for humanity.

The beginning of the movie from the get-go states that Seita and Setsuko will inevitably die by the end of the film. Both wind up dying from malnutrition with Seita a broken character with everyone in his family dying before him.

The ending is different between the anime and manga, but both still wind up quite depressing in the end. Anime features Chise failing to stop an attempted enemy invasion as everyone on the planet winds up dying with Shuji the last remaining human who may or may not be hallucinating about Chise the little speck of light. The manga features Chise wiping out the remaining human population on Earth as she turns into a giant spaceship to take Shuji to a new planet where they can start a new life together.

Depending on how you interpret the final scene of the anime, Suguru might be dying from wounds he sustained from a traitorous partner of his as the computer system for the Saints, Matthew, gives him a "final vision" of Mahoro.

Misuzu's inevitable death coming from Kanna's curse. Could also be considered a bittersweet ending as Misuzu was able to repair her relationship with aunt Haruko before death and winded up breaking Kanna's curse thanks to Yukito's magic.

Human Instrumentality Project, nuff said. XD

Everyone among the four factions fighting among one another, including main character Ichise, wind up dead from their bloody and intense gang war.

In the anime, Makoto is killed by Sekai for hooking back up with Kotonoha. Kotonoha winds up becoming mentally unstable as she severs the head of Makoto's corpse, kills Sekai by slicing her in the jugular plus cutting her stomach open and travels out to sea by boat while hugging Makoto's severed head. The manga features Kotonoha getting killed off by Sekai instead in the end so she can hook up with Makoto.

The anime might have been open ended. But the point in the plot it chose to end was at the point where things started to become an absolute hell for Guts and Caska with the Band of the Hawk getting slaughtered by countless apostles, Griffith turning into Femto and Caska getting raped by Femto in front of a helpless Guts.

Kazuki Fuse winds up being forced by his superiors in the Wolf Brigade to kill his lover, Kei Amamiya.

The manga ends with the entire human population being wiped out by giant hands created by the Earth as a result of Shiina becoming mentally broken from the loss of all her loved ones and Mamiko going berserk with the power as a result. Both girls wind up the last living humans on Earth with both pregnant setting up an "Adam and Eve" scenario.

Everyone on Earth winds up dead with Kiba failing to reach the gates of Paradise and his comrades being killed off by Darcia.

Everyone dies on Earth in an apocalyptic scenario triggered by the Countess of Werdenberg willingly allowing herself to merge with the creator of the Gilgamesh called Tear. Even with the newly created world desired by Tear, it is strongly hinted that the world would turn out no differently from the last one when Kiyoko's child winds up killing Tear because of her strong resemblance to the Countess from their merging.