He save the multiverse by stopping himself, who was going on a multiverse kill spree (it a pretty crazy story)
There no way of them taking him out for good, Deadpool is ban from dying all together because of Thanos. Bradley can't stay by Deadpool forever, he will grow old and die.
I believe it take Deadpool about 13 minutes to grow his head back and also Wolverine and Taskmaster in the fight to, who are at Deadpool's level. Lust is a nonfactor in the fight