@andr413: As long as Kirito has a beating heart Murasame's poison curse will work. Kirito would be a challenge for Akame but in the end who do you think is the better fighter? A child soldier who spent her whole childhood training to kill and many years of being an assassin under her belt? Or someone who has dabbled in a bit of kendo and survived a death game where you can live fatal blows if you have enough HP? Also I think the rules for battling in the forums say that Akame and Kirito know nothing about each other or their skills, meaning no before hand strategies. So Kirito has no information about Akame but Akame has been shown to gather information about her opponent while she is fighting. No matter how you look at it Akame has the advantage in this fight.