Since a young age, Itachi's intellect and talent have shown their brilliance in everything he did as even his teachers said his progress hardly required any help. In the few battles he has been seen in since the start of the series, Itachi was shown to be an extraordinarily powerful ninja, and easily one of the strongest shinobi in Naruto, as demonstrated by his ability to easily defeat Deidara and Kakashi Hatake, as well as having his skill praised by several people including Madara Uchiha and Orochimaru. By the time he was 13, he was already the most powerful ninja in the Uchiha Clan. Even when battling with a clone that had about thirty percent of his power, his skills allowed him to still be evenly matched with Kakashi and Naruto in Part II. He has demonstrated tremendous skill in all 3 forms of ninja combat. He is a master of the Sharingan, as he has demonstrated great talent with its abilities, such as its unique Genjutsu throughout the series. When faced with an opponent's Genjutsu, Itachi can use his Sharingan to dispel it or perform Demonic Illusion: Mirror Heaven and Earth Change and turn the Genjutsu against its user. Itachi is also noted to be very fast, both in his ability to maneuver and accelerate(when fighting Kurenai and Kakashi) along with his movements such as hand seals. Kakashi, an elite Jonin-Level ninja and fellow user of the Sharingan, had great difficulty keeping up with his speed as he couldn't see Itachi form any hand sign's when he proformed a jutsu. . Sasuke later commented on this speed in Part II during his fight with Itachi, since Itachi was capable of forming hand seals without them being noticed by Sasuke, while he was throwing multiple shuriken and defending Sasuke's attacks at the same time. Itachi also possesses the Mangekyo Sharingan, which increases his already great power, and enables him to use his most powerful techniques. With his left eye, he can use Tsukuyomi, a Genjutsu that traps an opponent's mind in an illusionary world, torturing them for what seems like days in a matter of seconds. With his right eye he can use Amaterasu, a Ninjutsu which allows him to create a black flame that he can direct with his eyesight to burn through almost anything in its path. His final technique is Susanoo, a technique that manifests as a spectral being made of chakra resembling a yamabushi with a tengu mask surrounding his body. It wields the Totsuka Sword, a spectral sword with the ability to bind what it cuts into an alternate dimension, trapping it in a Genjutsu state forever, and Yata's Mirror, a shield that can reflect many attacks. Zetsu, a fellow Akatsuki member, states that Itachi's mastery of the Sharingan's Eye Techniques and Genjutsu makes him invincible. Despite his mastery of the Mangekyo Sharingan, Itachi is falling prey to its side effects, as his eyesight is worsening after every activation and he will eventually go blind from its power, and his Sharingan will be forever sealed away.
In terms of standard Ninjutsu, Itachi can create shadow clones to perform techniques for him and act as shields from attacks. These clones can also be commanded to explode with Clone Great Explosion. As a member of the Uchiha clan, he can also perform "Fire Release: Great Fireball Technique" to catch opponents in a blast of fire, and in the anime can breathe multiple fireballs with Fire Release: Phoenix Immortal Fire Technique. With Water Release: Water Fang Bullet he can also catch targets in a circle of crushing water