For the kids we have Mera Hakamada's Fairy Idol Kanon, from Udon Entertainment, about three girls trying to save fairyland. The tweens get Tegami Bachi (that's TeGAmi Bachi, not TeGUmi Bachi, ICv2!), a dark fantasy (by which I mean, it's always dark out and there is no sun) about a letter carrier in a fantasy world.
But teens, of course, get the most: Osamu Tezuka's Black Jack, with absolutely no comparisons made whatsoever to House (it just seems like an obvious pop culture comparison; why doesn't someone send Hugh Laurie a copy of the book?), Masayuki Ishikawa's agricultural comedy Moyasimon (Del Rey's chosen spelling), and Karuho Shiina's Kimi Ni Todoke: From Me to You.
That's not to say we don't have some manga for us grown-ups (though frankly, I read Black Jack and I plan to pounce on Moyasimon, too): Fumi Yoshinaga's Ooku: The Inner Chamber, about a Japan where women rule and men die of the plague, resulting in men being protected-- in, for example, a female shogun's harem.
Good times all around. The only ones here I hadn't already attached myself to were Fairy Idol Kanon and Kimi Ni Todoke, but I guess I'll have to give 'em a shot.