Meisai is a former criminal who had a change of heart and now runs the Sanzu Shrine, a haven for battered and abused women. She wields the Sentou Tsurgi blade and fights using the Sentouryuu style, which involves utilizing your opponent's weapon as a form of self-defense.
The woman now known as Meisai Tsuruga was born the daughter of a kendo expert who would one day become a leader in Takahito Hida's army. As a child she was taught the She was the daughter of a Kenjo master and studied Sentouryuu, the art of ultimate self-defense. She fully believed in it as a child but when her father, who was a leader in the rebellion led by Takahito Hida, and all of his disciples were cut down, she turned her back on it and herself. She decided to join a group of bandits whose leader possessed Sentou Tsurugi and began to use Sentouryuu as an offensive style for wanton murder. Eventually she became the leader of the bandits and claimed the blade as her own. As she became more and more disillusioned, she came to Sanzu Shrine and murdered the leader, a man named Meisai Tsuruga whose name she later claimed, due to it being a shrine dedicated to helping young women who have suffered physical and psychological abuse and her feeling that it failed her in her life. Upon his death, the leader asked forgiveness for the girls of the shrine for they had done nothing wrong. This touched her heart and she decided to return to her bandit crew, murder all forty-three of them, and then returned to the shrine, claim Meisai's name as her own, and continue the work that he did.
Meisai is a character in the Katanagatari series of light novels written by Nishio Ishin, a popular Japanese writer, with illustrations by Take. She also appears in the anime series of the same name which was created by White Fox and directed by Keitaro Motonaga. Meisai, voiced by Atsuko Yuya, makes her first appearance in the anime series during Episode 3, "Blade, the Thousand".
Togame and Shichika Yasuri travel to the Sanzu Shrine to confront the current head of the its current leader who posses the Klesha Bringer Sentou Tsurugi. Upon their arrival they are greeted by Meisai, who invites Togame into the shrine to drink and discuss she and Shichika's reasons for being there, which she has already surmised. Meisai explains that she has been using the "poison" of Sentou Tsurugi to keep the battered women at the shrine calm and at peace in their life. Already aware of this, Togame offers to have the Shogunate assist the shrine in its task if Meisai would be willing to peacefully turn over the sword. Meisai refuses the offer, leading Togame to challenge her to a duel against Shichika over the swords and Meisai accepts.
Later that night, Meisai meets with Shichika and questions exactly why he fights and is willing to kill her to claim the swords when they are being used to aid the abused women working as shrine maidens. Shichika nonchalantly answers that it is simply because Togame asked him to and displays no emotion or concern over the ramifications his actions will have. Meisai is taken aback but the two continue with their conversation. Suddenly, they find themselves under attack by Kuizame Maniwa, a member of the Maniwa Corps who fights using chains. Shichika races out to attack him but Meisai beats him to the punch, saying that as the guardian of the shrine it is her duty to protect it from all attacker and proceeds to make short work of the ninja.
The next day, Shichika and Meisai begin their battle. In the midst of the battle, Meisai reveals her background but Shichika is unphased after hearing this and proceeds to defeat Mei by piercing her heart using the Koyouka Suigetsu attack in Kyotouryuu: Shichika Hachiretsu.
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