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Count the medals! 1, 2, and 3! Life goes on! Anything goes! Coming up OOO!
After escaping from their imprisonment the Greeed, a monstrous race that feeds off of human desire and avarice, scour Japan in search for sustenance.
However, one of the Greeed, a bird monster named Ankh, is only reborn as a floating hand without a body. Distrusting of his kin, he instead takes a riskier approach: granting someone the power of OOO, the hero who imprisoned them centuries before, into a patsy who will follow his commands and take the accumulated avarice for himself.
He finds one in easy going drifter named Eiji Hino, despite his strong moral fiber that gets in the way of Ankh's plans.
But there is another player in this game; a huge corporation with a large amount of knowledge on OOO and the Greed, and has long since developed technology that utilizes the materialized avarice (which takes the shape of medals) for their own ends.