Since this is of course Anime Vice, why just have one? Why not multiple vices at the same time? So I propose this question what is/would be an awesome anime drinking game. Example: Queens Blade, every time you see tits drink (including intro). This is going outside of anime, but my friends and I have been playing Bayonetta and we drink every time there's an obvious ass shot. This is directed at you fine 21 year old and up crowd and doesn't solely have to be related to any sexual behavior either or even a good anime. Some of the best drinking games come from laughably horrendous movies and shows.
@jlanzer: look at it this way, i once risk my life doing a bleach drinking game
everytime someone says "shikai" or "bankai" drink everytime someone says their zanpakuto name drink everytime an arrancar/villains curbstomps the hero drink and vice versa everytime orihime juggle drink everytime aizen shows how broken he is DRINK HALF A CAN
you either will have iron stomach or die after completing this oh here's another naruto game everytime sasuke asspulls drink everytime that ZA song and the ZA word comes take a drink everytime a new thing is made drink for every filler and movie one can everytime naruto uses his generic tactic drink
Pokemon drinking game: Every time Ash cheats (We're looking at you, Pikachu vs Rhydon) take a drink. Alternatively, Every time a character suffers from Plot Induced Stupidity (Possibly Palkia not bending space to reflect attacks), take a driink.