General Discussion

in your personally opinion what anime, that had been change from its manga so much that they ended up having huge differences in stroy or ending, was the one that differ from its manga the most.

examples:

soul eater

rosario vampire

Let's see...

The first Fullmetal Alchemist anime, which pretty much takes its own direction with the manga's plot as it was ongoing at the time.

Cardcaptor Sakura- Compared to the manga's 16 cards, the anime added in 36 more cards for Sakura to capture, featured Syaoran getting some cards (while he gets none in the manga) and a new supporting character, Meiling Li.

Full Moon o Sagashite- Compared to the manga's more somber and serious mood, the anime was mostly light-hearted in its exploration of Mitsuki's music career as Full Moon and gets increasingly more serious in later episodes. Whereas she was an immediate hit in the anime, Mitsuki had to struggle more at being a star in the manga. In addition, the manga provides more depth on characters who were otherwise underdeveloped in the anime like Meroko and Izumi. And speaking of Izumi, his character is much more likeable in the manga.

Kodocha- A lot of nutty comedy, filler episodes and breaking the fourth wall humor was incorporated into the anime, as the manga was a more traditional shoujo romantic dramedy in its focus on Sana and Hayama's relationship developments.

Love Hina- Will be a bit lengthy to cover here considering the different anime titles in the franchise.

• The TV anime had toned down on the manga's fan service, expanded on character back stories, changed around some events from the manga, added some new characters (Naru's sister Mei, Kentaro Sakata, Moe, etc...) and had a number of episodes that were anime-only storylines or filler.
• The Spring Special, which covers events from the manga's eighth volume, tones down fan service (only Naru dons her leaf bikini for much of the second half of the anime) and removes some events that occurred in the manga (being at the turtle civilization ruins, Naru's "issues" at the airport).
• Love Hina Again, based on the manga's 11th and 12th volumes, lacks the reveal on who Keitaro's "promised girl" really is and either removes or changes around events that occurred from the manga.

Berserk- From what I recall between the TV anime and manga, the anime toned down on the graphic violence and sexual content of the manga, removed some major scenes in the manga (the Band of the Hawk's battle with Wyald, Guts meeting the Skull Knight for the first time, how Guts escaped from the Abyss) and retained a consistently serious mood throughout its run removing some moments of light-hearted humor with the characters.

claymore: in the anime clare fights priscila and she defeats her. on the manga that doesnt happen and a timeskip occurs instead.

Add in some more stuff:

Fruits Basket- The anime removes some scenes from the manga, adds in its own storylines at points (especially in the show's finale), moved around or changes some of the manga's storylines (Tohru meeting Ritsu and Hiro happens after the incident with Kyo's "true form") and removes mention of certain character traits or hints to events that occur later in the manga (the red cap boy from Tohru's past, Shigure's sinister side, Momiji being half-German, etc...).

Neon Genesis Evangelion- The manga reduces the number of Angels for the Eva pilots to fight, changes around traits and/ or backgrounds of the characters (Shinji being a bit more assertive yet angry from Gendo's neglect, Rei behaving more "human", Asuka being a test tube baby, etc...) and changes a number of events from the anime.

Manga also has a notable moment that makes me like the manga take of Shinji over his anime counterparts. Look below: