If we're talking about technical stuff, I think Japanese animation is better at "big picture" things like making sure action sequences look amazing. US animation seems to be better at small stuff though, like making sure lip movements and vocals match up when the scene is normal (like two people just walking down a street), the animation is smoother than what I see in anime a lot of times.
On major negative for US animation though is that there seemed to be a trend that looking "bad" was cool. South Park, Family Guy, Ed Edd and Eddy, Rugrats and a bunch of others from all throughout the 90s and 00s seemed to be drawn in a way that's like we can draw well but it's cooler if we make everything like we really suck at drawing. The only anime that makes me feel that way is Crayon Shin-Chan and Kaasan: Mom's Life. Possibly related to that, the differences in art style between any two random US cartoons might be night and day while most anime seems more like mild variations on a handful of themes rather than something radically different.