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"A child with a mole in the path of their tears is destined to have a sorrowful life full of them." - Japanese Proverb
Chizuna Takashiro is Kazuna's elder sister by two years. She has had the blood-craving disease since early childhood. She also has heart problems. She has two moles below her left eye. "A child with a mole in the path of their tears is destined to have a sorrowful life full of them." - Japanese proverb printed in vol 3. Besides the Takashiro disease she also has heart problems, and the serum she takes to control the Takashiro disease seems to damage her heart and general health. Chizuna admits to having had a strange relationship with her father after her mother's death. By the way she speaks about their relationship, many have come to believe their relationship went beyond that of merely father/daughter. She seems to be using her brother as a replacement for his father, much like father had done with her, as a replacement for his wife. Dr. Minase is deeply in love with Chizuna and even attempted to take her away from her father but Chizuna could not leave him. She does her best to distance Yaegashi from Kazuna, claiming that only she can care for his needs. She also treats the Eda's coldly when she confronts them at the hospital and tells them of her and Kazuna's plans to live together. In a dream, Chizuna remembers her mother tried to kill her because she wanted to help Chizuna avoid a life filled with pain and suffering, but was killed by Chizuna. Shizuna constantly told Chizuna lies about her mother's death, to the point that she remembered nothing of it until her dream. Chizuna looks like her mother and dies at the end of both the manga and anime. On her deathbed, she tells Kazuna that he was never really her father's replacement and that she loves him for him, then releases him to Yaegashi because she believes that he can still have a life and overcome the disease.